![]() Specific recommendations are presented in a box at the beginning of each section, followed by explanations and data derived from relevant literature. It is organized in sections referring to the preanalytical, analytical and postanalytical phases of SF laboratory testing. This document is intended for laboratory professionals and all medical personnel involved in the synovial fluid collection and analysis. The ultimate goal is to improve patient safety and healthcare outcomes. It addresses the preanalytical, analytical, and postanalytical issues and clinical significance of tests used in SF analysis with the aim of improving the value of SF laboratory testing in the diagnosis of joint diseases and assisting in the achievement of national harmonization of SF testing. This recommendation is the second in the series of recommendations prepared by the members of the WG EBFS of the CSMBLM ( 7). These results, combined with a thorough review and critical assessment of all available scientific evidence, were used to design this document. The main results demonstrated that SF laboratory testing is rarely performed in Croatian medical biochemistry laboratories, and since the procedures used in other investigated extravascular body fluid testing are not harmonized, the same level of harmonization might be expected in SF laboratory testing ( 6). The Working group for extravascular body fluid samples (WG EBFS) of the Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM) conducted an extensive survey aimed at mapping critical areas in the preanalytical, analytical, and postanalytical phases of extravascular body fluids analysis in Croatia. Laboratory testing of SF can provide valuable information in establishing the diagnosis of a rheumatic condition, be a part of patient’s follow-up and treatment with the purpose of improving the patient’s health and quality of life ( 2- 5). Furthermore, the clinical significance of SF laboratory testing has been established in acute arthritis, especially in the diagnosis of septic and crystal arthritis, as well as intercritical gout. Distinguishing amongst non-inflammatory and inflammatory joint effusions is considered the most important clinical application of SF laboratory testing. Indications for SF laboratory testing include inflamed joints with a known or unknown aetiology, suspected acute prosthetic joint infection, as well as infection identification by microbiological analyses and diagnosing crystal-induced arthritis, etc. Laboratory testing of the SF can contribute to the differential diagnosis of rheumatic conditions accompanied with joint effusions. Joint disease is often accompanied by alterations in the composition and volume of synovial fluid (SF). They are among the leading causes of morbidity and disability worldwide and represent an enormous burden on healthcare systems ( 1). ![]() It is intended for laboratory professionals and all medical personnel involved in synovial fluid collection and testing.Ĭhronic rheumatic conditions comprise more than 150 different diseases (including joint disease) with an often progressive and generally painful nature. ![]() It addresses preanalytical, analytical, and postanalytical issues and the clinical significance of tests used in SF laboratory testing with the aim of improving the value of SF laboratory testing in the diagnosis of joint diseases and assisting in the achievement of national harmonization. This document is the second in the series of recommendations prepared by the members of the Working group for extravascular body fluid samples of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Consequently, procedures for SF laboratory testing are poorly harmonized. Synovial fluid laboratory testing is rarely performed in Croatian medical biochemistry laboratories. Laboratory testing of SF can provide valuable information in establishing the diagnosis, be a part of a patient’s follow-up and treatment with the purpose of improving the patient’s health and quality of life. Synovial fluid (SF) laboratory testing is an important part of a diagnostic evaluation of patients with joint diseases. Joint diseases are conditions with an often progressive and generally painful nature affecting the patient’s quality of life and, in some cases, requiring a prompt diagnosis in order to start the treatment urgently.
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